LATEST NEWS


Biotechniques features our targeted methylation research
July 8, 2014
Biotechniques published a feature last month on Brian Chaikind's PLoS One paper on targeted DNA methylation.



Another new NSF grant
June 17, 2014
More good news from NSF. The lab received a grant from the NSF-DEB Evolutionary Genetics Program to study epistasis.



Brian's paper on improved targeted methyltransferases published
May 8, 2014
Brian's paper on the creation of highly specific DNA methyltransrerases was published today in PLoS One.


New NSF grant on directed evolution
April 21, 2014
The lab received a new grant from the NSF-CBET Biotechnology, Biochemical, and Biomass Engineering Program to explore alternative pathways in directed evolution.



Tiana Warren offered two fellowships
April 18, 2014
Congratulations to Tiana Warren for being selected to receive both an NSF Predoctoral Fellowship and a Ford Foundation Fellowship. Tiana plans to accept the NSF Fellowship.



Marc Ostermeier elected to AIMBE
March 24, 2014
Marc Ostermeier was elected as a Fellow in the American Institute for Medical and Biological Engineering.



Dr. Clay Wright!
March 14, 2014
Congratulations to Clay Wright for successfully defending his thesis today. Next up for Clay (besides getting married) is a postdoc at The University of Washington with Jennifer Nemhauser in the Department of Biology.



Elad's fitness landscape paper published
February 23, 2014
Elad's paper describing a comprehensive map of the mutational landscape of the TEM-1 β-lactamase gene was published online today in Molecular Biology and Evolution.



Dr. Brian Chaikind!
January 17, 2014
Congratulations to Brian Chaikind for successfully defending his thesis today. Next up for Brian is a postdoc at Harvard with David Liu.


LATEST PUBLICATIONS


B.Chaikind, M. Ostermeier
Directed evolution of improved zinc finger methyltransferases
PLoS One, 9(5): e96931 (2014) [full text]

E. Firnberg, J. W. Labonte, J. J. Gray, M. Ostermeier
A comprehensive, high-resolution map of a gene's fitness landscape
Mol. Bio. Evol., 31, 1581-1592 (2014) [PDF]

E. Firnberg, M. Ostermeier
The genetic code constrains yet facilitates Darwinian evolution
Nucleic Acids Res., 41, 7420-7428 (2013) [full text]

J. H. Choi, A. San, M. Ostermeier
Non-allosteric enzyme switches possess larger effector-induced changes in thermodynamic stability than their non-switch analogs
Protein Sci., 22, 475-485 (2013) [PDF]





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        Mutational tolerance in TEM-1 β-lactamase.