I develop and characterize biophysical assays to study how collagen concentration affects the growth of multicellular cancer spheroids embedded in completely 3D environments. I’m particularly interested in mimicking and understanding the complex interplay between the extracellular matrix near a growing tumor and locally invading cancer cells.
1. Discovered and characterized a distinct division phenotype of mammalian cells in 3D collagen matrix.2. Investigating the molecular basis behind the accurate prediction of division orientation by cellular protrusion in 3D matrix.3. Probing the transition of cells from 2D substrate to 3D matrix at both cellular and molecular levels.
Leonor Guedes da SilvaVisiting scholar