Cell migration is important for various biological processes, such as embryogenesis, wound healing, inflammatory response, and cancer metastasis. Much of what we know about cell migration has stemmed from studies performed on flat two-dimensional (2D) substrates, but cell migration in vivo predominantly occurs through three-dimensional (3D) matrices and not much is known about what molecules matter, how cells interact with the extracellular matrix (ECM), how cells sense and navigate the ECM etc. In the wirtz lab, we are making strides towards understanding this complex and intricate cellular process.
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