The actin cap

The perinuclear actin cap (or actin cap) is a recently characterized cytoskeletal organelle composed of thick, parallel, and highly contractile acto-myosin filament bundles that are physically, yet dynamically, connected to the nuclear envelope through linkers of nucleoskeleton and cytoskeleton (LINC) complexes and terminated by actin-cap-associated focal adhesions (ACAFAs) at the basal surface of the adherent cells. The actin cap is present in a wide range of adherent eukaryotic cells, but is disrupted in several human diseases, including laminopathies and cancer. Due to the distinct topology, the actin cap plays a critical role in regulating nuclear morphology and movement, cell migration, cellular mechanosensation and mechanotransduction, as well as intranuclear reshaping and chromosomal organization.

actin_cap

References:

Kim et al., “Tight coupling between nucleus and cell migration through the perinuclear actin cap”, Journal of Cell Science (2014)

Kim et al., “The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction”, Soft Matter (2013)

Chambliss et al., “The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction”, Scientific Reports (2012)

Kim et al., “Actin cap associated focal adhesions and their distinct role in cellular mechanosensing”, Scientific Reports (2012)

Khatau et al., “The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells”, PLOS One (2012)

Khatau et al., “The perinuclear actin cap in health and disease”, Nucleus (2010)

Khatau et al., “A perinuclear actin cap regulates nuclear shape”, PNAS (2009)