The perinuclear actin cap (or actin cap) is a recently characterized cytoskeletal organelle composed of thick, parallel, and highly contractile acto-myosin filament bundles that are physically, yet dynamically, connected to the nuclear envelope through linkers of nucleoskeleton and cytoskeleton (LINC) complexes and terminated by actin-cap-associated focal adhesions (ACAFAs) at the basal surface of the adherent cells. The actin cap is present in a wide range of adherent eukaryotic cells, but is disrupted in several human diseases, including laminopathies and cancer. Due to the distinct topology, the actin cap plays a critical role in regulating nuclear morphology and movement, cell migration, cellular mechanosensation and mechanotransduction, as well as intranuclear reshaping and chromosomal organization.
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